Potassium Carbonate → N-Cyclopropyl-4-methyl-3-(1-oxo-2-(1-phenylethyl)-1,2-dihydroisoquinolin-6-yl)benzamide

Participants

Reaction Conditions

Reaction Steps

A mixture of the product of Example 11 (200 mg), potassium carbonate (260 mg) and (1-bromoethyl)benzene (0.100 mL) in DMF (2 mL) was stirred at 80° C. for 17 hours. Further (1-bromoethyl)benzene (0.100 mL) and potassium carbonate (260 mg) was added and stirred at 80° C. for a further 24 hours. Additional (1-bromoethyl)benzene (0.5 mL) and potassium carbonate (500 mg) were added and the reaction stirred at 80° C. for a further 48 hours. The reaction mixture was filtered and purified by HPLC to yield the title compound (14 mg) as a solid.

Provenance & Evidence