反应详情

温度

80 °C

A mixture of the product of Example 11 (200 mg), potassium carbonate (260 mg) and (1-bromoethyl)benzene (0.100 mL) in DMF (2 mL) was stirred at 80° C. for 17 hours. Further (1-bromoethyl)benzene (0.100 mL) and potassium carbonate (260 mg) was added and stirred at 80° C. for a further 24 hours. Additional (1-bromoethyl)benzene (0.5 mL) and potassium carbonate (500 mg) were added and the reaction stirred at 80° C. for a further 48 hours. The reaction mixture was filtered and purified by HPLC to yield the title compound (14 mg) as a solid.

1. stirringstirred at 80° C. for a further 24 hours
2. stirringthe reaction stirred at 80° C. for a further 48 hours
3. filtrationThe reaction mixture was filtered
4. custompurified by HPLC