HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 907350Generated: October 31, 2026
Potassium Carbonate → N-Cyclopropyl-3-(2-(2-ethylbutyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide
https://huagongshe.com/reaction/907350
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Pentane, 3-(bromomethyl)- | HCID 77432 | — |
| Reactant | N-Cyclopropyl-4-methyl-3-(1-oxo-1,2-dihydro-isoquinolin-6-yl)-benzamide | HCID 25020457 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-Cyclopropyl-3-(2-(2-ethylbutyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide | HCID 57551735 | — |
Reaction Steps
To a solution of the product of Example 11 (100 mg) in DMF (3 mL) was added potassium carbonate (217 mg) followed by 3-(bromomethyl)pentane (0.44 mL) and the mixture stirred at 80° C. for 17 hrs. The reaction mixture was filtered and purified by HPLC to give the title compound (55.0 mg) as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08012979B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-48535875f14b4f9397e9755f43da321d |
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| Source note | uspto-grants-2011_09 |
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