反应详情

温度

80 °C

To a solution of the product of Example 11 (100 mg) in DMF (3 mL) was added potassium carbonate (217 mg) followed by 3-(bromomethyl)pentane (0.44 mL) and the mixture stirred at 80° C. for 17 hrs. The reaction mixture was filtered and purified by HPLC to give the title compound (55.0 mg) as a solid.

1. filtrationThe reaction mixture was filtered
2. custompurified by HPLC