Picolyl chloride hydrochloride → N-Cyclopropyl-4-methyl-3-(1-oxo-2-(pyridin-2-ylmethyl)-1,2-dihydroisoquinolin-6-yl)benzamide

HRID 907353Notes

Reaction equation

HRID 907353 reaction equation
[CH:1]1([NH:4][C:5](=[O:24])[C:6]2[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[C:19](=[O:23])[NH:18][CH:17]=[CH:16]4)[CH:7]=2)[CH2:3][CH2:2]1.Cl.Cl[CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=1>>[CH:1]1([NH:4][C:5](=[O:24])[C:6]2[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[C:19](=[O:23])[N:18]([CH2:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=3)[CH:17]=[CH:16]4)[CH:7]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 23392Picolyl chloride hydrochlorideHCID 25020457N-Cyclopropyl-4-methyl-3-(1-oxo-1,2-dihydro-isoquinolin-6-yl)-benzamide

Product 1

HCID 57551719N-Cyclopropyl-4-methyl-3-(1-oxo-2-(pyridin-2-ylmethyl)-1,2-dihydroisoquinolin-6-yl)benzamide

Procedure

The title compound was prepared according to the method of Example 123 using the product of Example 11 and 2-(chloromethyl)pyridine hydrochloride.

Sources & evidence

ORD record
ord-8dd7c091419149d999865dbb6af7d289
Source dataset
uspto-grants-2011_09
Patent number
US08012979B2

Reaction notes

Loading…