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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 907353Generated: November 1, 2026

Picolyl chloride hydrochloride → N-Cyclopropyl-4-methyl-3-(1-oxo-2-(pyridin-2-ylmethyl)-1,2-dihydroisoquinolin-6-yl)benzamide

https://huagongshe.com/reaction/907353

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPicolyl chloride hydrochlorideHCID 23392—
ReactantN-Cyclopropyl-4-methyl-3-(1-oxo-1,2-dihydro-isoquinolin-6-yl)-benzamideHCID 25020457—
ProductN-Cyclopropyl-4-methyl-3-(1-oxo-2-(pyridin-2-ylmethyl)-1,2-dihydroisoquinolin-6-yl)benzamideHCID 57551719—

Reaction Steps

The title compound was prepared according to the method of Example 123 using the product of Example 11 and 2-(chloromethyl)pyridine hydrochloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08012979B2
Source datasetuspto-grants-2011_09
ORD IDord-8dd7c091419149d999865dbb6af7d289
Source noteuspto-grants-2011_09