(1,4-Dibenzyl-1,4-diazepan-5-yl)methanol → HCID 23090220, compound

HRID 907354Notes

Reaction equation

HRID 907354 reaction equation
C([N:8]1[CH2:14][CH2:13][CH:12]([CH2:15][OH:16])[N:11](CC2C=CC=CC=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[NH:8]1[CH2:14][CH2:13][CH:12]([CH2:15][OH:16])[NH:11][CH2:10][CH2:9]1

Participants

5

Reactant 2

HCID 67401084(1,4-Dibenzyl-1,4-diazepan-5-yl)methanolHCID 178418361HCID 178418361, compound

Product 1

HCID 23090220HCID 23090220, compoundYield 100.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of (1,4-dibenzyl-1,4-diazepan-5-yl)methanol (500 mg) (prepared as described in Chin. Chem. Lett., 2001, 12, 951) in methanol (10 mL) was added 5% wt. palladium on charcoal (171 mg) and the mixture stirred under a 5 bar hydrogen atmosphere for 16 hours. The reaction mixture was filtered through celite and the liquors concentrated to dryness to give the sub-title compound (210 mg) as a colourless oil.

Workup

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe liquors concentrated to dryness

Sources & evidence

ORD record
ord-f41b54ce16414a538199451ef273fd1c
Source dataset
uspto-grants-2011_09
Patent number
US08012979B2

Reaction notes

Loading…