反应详情

A solution of 1-methyl-4-nitro-1H-pyrrole-2-carbonyl chloride (0.254 g, 1.35 mmol; see Preparation 1(ii) above) in DCM (10 mL), is added dropwise to a solution of DMPA (0.153 g, 5.05 mmol) (Aldrich), NEt3 (0.152 g, 1.5 mmol), in DCM (10 mL) over 15 min. The resulting solution was allowed to stir overnight, before quenching the reaction with a 5% NaOH solution (20 mL). The DCM fraction was then dried over MgSO4, filtered and the solvent removed under reduced pressure to yield the sub-title compound (0.254 g, 74%).

1. custombefore quenching
2. customthe reaction with a 5% NaOH solution (20 mL)
3. dry with materialThe DCM fraction was then dried over MgSO4
4. filtrationfiltered
5. customthe solvent removed under reduced pressure