Thionyl Chloride → HCID 11310415, compound

HRID 907376Notes

Reaction equation

HRID 907376 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([CH2:11]O)[CH:2]=1.O=S(Cl)[Cl:15]>C(Cl)Cl>[Cl-:15].[Cl:15][CH2:11][C:3]1[CH:2]=[NH+:1][C:10]2[C:5]([CH:4]=1)=[CH:6][CH:7]=[CH:8][CH:9]=2

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 12662983(Quinolin-3-yl)methanol

Product 1

HCID 11310415HCID 11310415, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-Quinolinylmethanol (that prepared step (i) above) was dissolved in DCM (2 mL) and SOCl2 (5 mL) was added (dropwise initially) to the solution, which was then refluxed for 1 h. The DCM and excess SOCl2 were then removed under reduced pressure to yield the sub-title compound, which was employed directly in the next step without further purification.

Workup

  1. temperaturewas then refluxed for 1 h
  2. customThe DCM and excess SOCl2 were then removed under reduced pressure

Sources & evidence

ORD record
ord-34931a233ecb4119bc7a7207ce9c5121
Source dataset
uspto-grants-2011_09
Patent number
US08012967B2

Reaction notes

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