Sodium Hydroxide → HCID 42611645, compound

HRID 907382Notes

Reaction equation

HRID 907382 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1/[CH:11]=[CH:12]/[C:13]1[S:14][CH:15]=[C:16]([C:18]([O-:20])=[O:19])[N:17]=1.[OH-].[Na+]>C(O)C.O>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1/[CH:11]=[CH:12]/[C:13]1[S:14][CH:15]=[C:16]([C:18]([OH:20])=[O:19])[N:17]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 131729163HCID 131729163, compound

Product 1

HCID 42611645HCID 42611645, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Conditions

Temperature
0 °C

Procedure

2-[(E)-2-(2-Quinolinyl)ethenyl]-1,3-thiazole-4-carboxylate (0.137 g, 0.44 mmol; see step (vi) above) was suspended in ethanol (2 mL), NaOH (0.052 g, 1.32 mmol) in water (5 mL) was added and the solution was then refluxed for 2 h. The reaction was then hot-filtered and then cooled to 0° C., whereupon dilute HCl was added dropwise until the title compound precipitated as a yellow solid (0.103 g, 83%).

Workup

  1. temperaturethe solution was then refluxed for 2 h
  2. filtrationThe reaction was then hot-filtered
  3. additionwas added dropwise until the title compound
  4. customprecipitated as a yellow solid (0.103 g, 83%)

Sources & evidence

ORD record
ord-a1d62091158f4a3db06d061a4104343e
Source dataset
uspto-grants-2011_09
Patent number
US08012967B2

Reaction notes

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