Sodium Hydroxide → HCID 42611645, compound

Participants

Reaction Conditions

Reaction Steps

2-[(E)-2-(2-Quinolinyl)ethenyl]-1,3-thiazole-4-carboxylate (0.137 g, 0.44 mmol; see step (vi) above) was suspended in ethanol (2 mL), NaOH (0.052 g, 1.32 mmol) in water (5 mL) was added and the solution was then refluxed for 2 h. The reaction was then hot-filtered and then cooled to 0° C., whereupon dilute HCl was added dropwise until the title compound precipitated as a yellow solid (0.103 g, 83%).

Provenance & Evidence