反应详情

温度

0 °C

Total alkaloids (3.5 kg) containing 40% galanthamine, obtained according to example 1, are dissolved in 20 l of 95% ethanol. The solution is cooled to 0° C. and treated under stirring with 2.1 l of 48% aqueous hydrobromic acid, keeping the temperature during the addition between 0 and 5° C. The mixture is left under stirring at room temperature for four hours, the product is collected by filtration, washed with 95% ethanol and dried under vacuum at 60° C. 2.22 kg of galanthamine hydrobromide are obtained having HPLC purity of 88%. The mother liquors from filtration, which contain traces of galanthamine hydrobromide, are removed.

1. customobtained
2. additiontreated
3. additionduring the addition between 0 and 5° C
4. waitThe mixture is left
5. filtrationthe product is collected by filtration
6. washwashed with 95% ethanol
7. customdried under vacuum at 60° C