Hydroxyamine hydrochloride → HCID 86616107, compound

HRID 907442Notes

Reaction equation

HRID 907442 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([O:8][C:9]2[CH:14]=[CH:13][C:12]([NH:15][C:16]([NH:18][CH2:19][CH3:20])=[O:17])=[C:11]([Cl:21])[CH:10]=2)[C:3]=1[CH:22]=O.Cl.[OH:25][NH2:26]>>[NH2:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([O:8][C:9]2[CH:14]=[CH:13][C:12]([NH:15][C:16]([NH:18][CH2:19][CH3:20])=[O:17])=[C:11]([Cl:21])[CH:10]=2)[C:3]=1[CH:22]=[N:26][OH:25]

Participants

3

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 86616108HCID 86616108, compound

Product 1

HCID 86616107HCID 86616107, compound

Procedure

Using the procedure for Example 1, 1-[4-(6-amino-5-formyl-pyrimidin-4-yloxy)-2-chloro-phenyl]-3-ethyl-urea Compound 26b was reacted with hydroxy-amine hydrochloride to provide 1-{4-[6-amino-5-(hydroxyimino-methyl)-pyrimidin-4-yloxy]-2-chloro-phenyl}-3-ethyl-urea Compound 27a.

Sources & evidence

ORD record
ord-82b3a78c0e754f58ad317fabf34d90c0
Source dataset
uspto-grants-2011_09
Patent number
US08013153B2

Reaction notes

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