Tris(2-aminoethyl)amine → HCID 131729170, compound

HRID 907451Notes

Reaction equation

HRID 907451 reaction equation
[NH:1](C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O)[C@H:2]([C:9]([NH:11][C@H:12]([C:25]([O:27][CH3:28])=[O:26])[CH2:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[CH:16][CH:15]=1)=[O:10])[CH2:3][O:4][C:5]([CH3:8])([CH3:7])[CH3:6].[CH2:46](N)[CH2:47]N(CCN)CCN>C(OCC)(=O)C>[NH2:1][C@H:2]([C:9]([NH:11][C@H:12]([C:25]([O:27][CH2:28][CH:46]=[CH2:47])=[O:26])[CH2:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][C:21]([CH3:23])([CH3:22])[CH3:24])=[CH:16][CH:15]=1)=[O:10])[CH2:3][O:4][C:5]([CH3:8])([CH3:7])[CH3:6]

Participants

4

Reactant 2

HCID 77731Tris(2-aminoethyl)amineHCID 131729171HCID 131729171, compound

Product 1

HCID 131729170HCID 131729170, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

According to the general procedure for Fmoc-cleavage, 9 g Fmoc-Ser(tBu)-Tyr(tBu)-OMe, 22 ml TAEA in ethyl acetate yielded 4.7 g of crude product (yield based on HPLC: 88%).

Sources & evidence

ORD record
ord-2dc9aed2ba0c467cbdee45da8be596b5
Source dataset
uspto-grants-2011_09
Patent number
US08013117B2

Reaction notes

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