反应详情

To a suspension of 12 (141 g, 636 mmol) in THF (1.2 L) and MeOH (700 ml) in an ice bath was added slowly sodium methoxide (144 ml of a 25% solution in MeOH, 1.05 equiv). At the end of the addition, the bath was removed and the mixture stirred at r.t. for 1 h. The solvents were than evaporated and the remaining solid was triturated in ether containing a small amount of EtOAc. The slightly hygroscopic white solid was filtered and dried under high vacuum o.n. to yield 108.7 g (98%) of 13.

1. additionAt the end of the addition
2. customthe bath was removed
3. customthan evaporated
4. customthe remaining solid was triturated in ether containing a small amount of EtOAc
5. filtrationThe slightly hygroscopic white solid was filtered
6. customdried under high vacuum o.n