反应详情

The sulfonamide 14 (31.7 g, 138 mmol) was dissolved into boiling EtOH (600 ml) containing some AcOH (80 ml). To this solution was added 10% Pd/C (1.4 g) and this mixture was stirred under hydrogen (40 psi) for 3 h. THF (50 ml) was then added and this mixture heated to dissolve the precipitated product. This solution was filtered through celite and concentrated. The resulting solid was triturated with ether:hexane 1:1 (200 ml) to yield 27.28 g (99%) of pure 15.

1. temperaturethis mixture heated
2. dissolutionto dissolve the precipitated product
3. filtrationThis solution was filtered through celite and
4. concentrationconcentrated
5. customThe resulting solid was triturated with ether:hexane 1:1 (200 ml)
6. customto yield 27.28 g (99%) of pure 15