反应详情

温度

150 °C

A mixture of SeO2 (10.89 g, 99 mmol) and 6-methylquinoline (12.87 g, 90 mmol) was heated to 150° C. and stirred for 16 h. Then it was cooled to room temperature and EtOAc (400 ml) was added. After filtration, the filtrate was concentrated to obtain the crude compound, which was purified by chromatography (silica gel, petroleum ether/EtOAc 5:1 to 2:1) to afford the title compound (2.87 g, yield 20%). LC-MS (ESI) m/z: 158 (M+1)+.

1. temperatureThen it was cooled to room temperature
2. filtrationAfter filtration
3. concentrationthe filtrate was concentrated
4. customto obtain the crude compound, which
5. customwas purified by chromatography (silica gel, petroleum ether/EtOAc 5:1 to 2:1)