反应详情

温度

-20 °C

To a mixture of ethyl 1-phenylbicyclo[2.2.2]octane-4-carboxylate (Intermediate 4; 15 g, 58.06 mmol) and N,O-dimethylhydroxylamine hydrochloride (8.87 g, 89.99 mmol) in anhydrous THF (130 mL) cooled to −20° C. was added isopropylmagnesium chloride (2M solution in THF; 87 mL) dropwise over 30 mins maintaining the internal temp at −10° C. The mixture was stirred at −10° C. for 1 hr and then quenched by adding 20% ammonium chloride solution. The mixture was extracted into EtOAc (2×200 mL), the organic phase was separated and dried and evaporated to leave a white solid. This was purified on a 330 g Crawford silica cartridge, loading in DCM and eluting with 20-40% EtOAc-isohexane, to provide the title compound as a white solid (8.66 g, 31.67 mmol, 55%); 1H NMR (CDCl3) δ 1.75-1.90 (6H, m), 2.01-2.06 (6H, m), 3.19 (3H, s), 3.70 (3H, s), 7.15-7.20 (1H, m), 7.28-7.36 (4H, m); GC-MS EI+ m/e 243 (M−CH2O), MH+ not seen

1. temperaturemaintaining the internal temp at −10° C
2. customquenched
3. additionby adding 20% ammonium chloride solution
4. extractionThe mixture was extracted into EtOAc (2×200 mL)
5. customthe organic phase was separated
6. customdried
7. customevaporated
8. customto leave a white solid
9. customThis was purified on a 330 g Crawford silica cartridge, loading in DCM
10. washeluting with 20-40% EtOAc-isohexane