反应详情

温度

5 °C

To a stirred solution of Step 3 product (1 eq) and trimethyl orthoformate (4.00 eq) in MeOH (9.4 v/w) at 5° C. was bubbled HCl gas (approximately 5 eq) over 2 hours, maintaining a pot temperature of 5° C. Upon complete addition, the reaction mixture, under nitrogen, was heated to, and stirred at, reflux for 30 minutes.

1. additionUpon complete addition
2. temperaturethe reaction mixture, under nitrogen, was heated to, and
3. temperaturereflux for 30 minutes