Methanol → Methyl 1-methyl-4-nitro-1H-pyrrole-2-carboxylate

Participants

Reaction Steps

A cold solution of H2SO4 (2.9 mL) in MeOH (28.96 mL) was added to 1-methyl-4-nitropyrrole-2-carboxylic acid (2.897 g, 2.35 mmol). The mixture was refluxed for 24 hr. Water was added and the mixture extracted CHCl3. The organic layer was dried (MgSO4), and the solvent evaporated under vacuum to afford the creamy white product. NMR as previously reported.

Provenance & Evidence