4-[4-Methyl-2-(pyrazin-2-ylamino)-thiazol-5-yl]-benzenesulfonamide → 4-[2-(6-Methoxy-pyrazin-2-ylamino)-4-methyl-thiazol-5-yl]-N-methyl-benzene-sulfonamide

HRID 908146Notes

Reaction equation

HRID 908146 reaction equation
[CH3:1][NH:2][S:3]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][C:13](=O)[CH3:14])=[CH:8][CH:7]=1)(=[O:5])=[O:4].[CH3:16][O:17][C:18]1[N:23]=[C:22]([NH:24][C:25]([NH2:27])=[S:26])[CH:21]=[N:20][CH:19]=1.CC1N=C(NC2C=NC=CN=2)SC=1C1C=CC(S(N)(=O)=O)=CC=1>>[CH3:16][O:17][C:18]1[N:23]=[C:22]([NH:24][C:25]2[S:26][C:12]([C:9]3[CH:10]=[CH:11][C:6]([S:3]([NH:2][CH3:1])(=[O:5])=[O:4])=[CH:7][CH:8]=3)=[C:13]([CH3:14])[N:27]=2)[CH:21]=[N:20][CH:19]=1

Participants

4

Reactant 3

HCID 99282444-[4-Methyl-2-(pyrazin-2-ylamino)-thiazol-5-yl]-benzenesulfonamideHCID 21948402(6-Methoxy-pyrazin-2-yl)-thioureaHCID 58436479N-Methyl-4-(2-oxopropyl)benzene-1-sulfonamide

Product 1

HCID 866062074-[2-(6-Methoxy-pyrazin-2-ylamino)-4-methyl-thiazol-5-yl]-N-methyl-benzene-sulfonamide

Procedure

Using N-methyl-4-(2-oxo-propyl)-benzenesulfonamide (18a) and (6-methoxy-pyrazin-2-yl)-thiourea in an identical process to that described for the preparation of 4-[4-methyl-2-(pyrazin-2-ylamino)-thiazol-5-yl]-benzenesulfonamide (Example 1) afforded the title compound.

Sources & evidence

ORD record
ord-af718fd67b84442c830079787c689f90
Source dataset
uspto-grants-2011_09
Patent number
US08017608B2

Reaction notes

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