HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[4-Methyl-2-(pyrazin-2-ylamino)-thiazol-5-yl]-benzenesulfonamide → 4-[2-(6-Methoxy-pyrazin-2-ylamino)-4-methyl-thiazol-5-yl]-N-methyl-benzene-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[4-Methyl-2-(pyrazin-2-ylamino)-thiazol-5-yl]-benzenesulfonamide | HCID 9928244 | — |
| Reactant | (6-Methoxy-pyrazin-2-yl)-thiourea | HCID 21948402 | — |
| Reactant | N-Methyl-4-(2-oxopropyl)benzene-1-sulfonamide | HCID 58436479 | — |
| Product | 4-[2-(6-Methoxy-pyrazin-2-ylamino)-4-methyl-thiazol-5-yl]-N-methyl-benzene-sulfonamide | HCID 86606207 | — |
Reaction Steps
Using N-methyl-4-(2-oxo-propyl)-benzenesulfonamide (18a) and (6-methoxy-pyrazin-2-yl)-thiourea in an identical process to that described for the preparation of 4-[4-methyl-2-(pyrazin-2-ylamino)-thiazol-5-yl]-benzenesulfonamide (Example 1) afforded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08017608B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-af718fd67b84442c830079787c689f90 |
| Source note | uspto-grants-2011_09 |