4-Aminophenylacetone → 1-(4-Amino-3-chlorophenyl)propan-2-one

HRID 908148Notes

Reaction equation

HRID 908148 reaction equation
[Cl:1]NC(=O)CCC(N)=O.[NH2:10][C:11]1[CH:16]=[CH:15][C:14]([CH2:17][C:18](=[O:20])[CH3:19])=[CH:13][CH:12]=1>C(Cl)(Cl)Cl>[NH2:10][C:11]1[CH:12]=[CH:13][C:14]([CH2:17][C:18](=[O:20])[CH3:19])=[CH:15][C:16]=1[Cl:1]

Participants

4

Reactant 2

HCID 117883794-AminophenylacetoneHCID 15238416N-chlorosuccinamide

Product 1

HCID 580124851-(4-Amino-3-chlorophenyl)propan-2-one

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

N-Chlorosuccinamide (1.79 g, 13.4 mmol) is added to a stirred solution of 1-(4-amino-phenyl)-propan-2-one (2.0 g, 13.4 mmol) in chloroform at 0° C. After 1 hour the reaction is complete. The solvent is removed to give the title compound.

Workup

  1. customThe solvent is removed

Sources & evidence

ORD record
ord-679a2e7e43a647429ca8cccd7dd4b52e
Source dataset
uspto-grants-2011_09
Patent number
US08017608B2

Reaction notes

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