1-(4-Amino-3-chlorophenyl)propan-2-one → 4-(2-Chloro-4-methyl-thiazol-5-yl)-benzenesulfonamide

HRID 908156Notes

Reaction equation

HRID 908156 reaction equation
[Cl:1][C:2]1[S:3][C:4]([C:8]2[CH:13]=[CH:12][C:11](N)=[CH:10][CH:9]=2)=[C:5]([CH3:7])[N:6]=1.ClC1C=C(CC(=O)C)C=CC=1[S:26]([NH2:29])(=[O:28])=[O:27].NC1C=CC(CC(=O)C)=CC=1Cl>>[Cl:1][C:2]1[S:3][C:4]([C:8]2[CH:13]=[CH:12][C:11]([S:26]([NH2:29])(=[O:28])=[O:27])=[CH:10][CH:9]=2)=[C:5]([CH3:7])[N:6]=1

Participants

4

Reactant 3

HCID 580124851-(4-Amino-3-chlorophenyl)propan-2-oneHCID 673917572-Chloro-4-(2-oxo-propyl)-benzenesulfonamideHCID 673917684-(2-Chloro-4-methyl-thiazol-5-yl)-phenylamine

Product 1

HCID 673920414-(2-Chloro-4-methyl-thiazol-5-yl)-benzenesulfonamide

Procedure

Starting from 4-(2-chloro-4-methyl-thiazol-5-yl)-phenylamine (25c) and following the two step process described for the preparation of 2-chloro-4-(2-oxo-propyl)-benzenesulfonamide (Example 23c) from 1-(4-amino-3-chloro-phenyl)-propan-2-one (Example 23a) gave the title compound.

Sources & evidence

ORD record
ord-2ed7c4af63cc429aa319e6d97dcfbf5d
Source dataset
uspto-grants-2011_09
Patent number
US08017608B2

Reaction notes

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