1-Methylpiperazine → HCID 86606213, compound

Participants

Reaction Steps

A stirred solution of N-methyl piperazine (0.184 g, 1.84 mmol) and (6-chloro-pyridin-3-yl)-[5-(4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-amine (31c) (0.070 g, 0.184 mmol) in DMSO (2 ml) is heated in a microwave (PROLABO SYNTHEWAVE s402™) at 60% power (180 W) for 10 hours. The solvent is removed and the residue is purified by chromatography on silica eluting with ethyl acetate-methanol (9:1) to give the title compound as a yellow solid (0.096 g).

Provenance & Evidence