1-Methylpiperazine → HCID 86606213, compound

HRID 908166Notes

Reaction equation

HRID 908166 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.Cl[C:9]1[N:14]=[CH:13][C:12]([NH:15][C:16]2[S:17][C:18]([C:22]3[CH:27]=[CH:26][C:25]([S:28]([CH3:31])(=[O:30])=[O:29])=[CH:24][CH:23]=3)=[C:19]([CH3:21])[N:20]=2)=[CH:11][CH:10]=1>CS(C)=O>[CH3:31][S:28]([C:25]1[CH:26]=[CH:27][C:22]([C:18]2[S:17][C:16]([NH:15][C:12]3[CH:13]=[N:14][C:9]([N:5]4[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]4)=[CH:10][CH:11]=3)=[N:20][C:19]=2[CH3:21])=[CH:23][CH:24]=1)(=[O:30])=[O:29]

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 86606214HCID 86606214, compound

Product 1

HCID 86606213HCID 86606213, compoundYield 117.6%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

A stirred solution of N-methyl piperazine (0.184 g, 1.84 mmol) and (6-chloro-pyridin-3-yl)-[5-(4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-amine (31c) (0.070 g, 0.184 mmol) in DMSO (2 ml) is heated in a microwave (PROLABO SYNTHEWAVE s402™) at 60% power (180 W) for 10 hours. The solvent is removed and the residue is purified by chromatography on silica eluting with ethyl acetate-methanol (9:1) to give the title compound as a yellow solid (0.096 g).

Workup

  1. customThe solvent is removed
  2. customthe residue is purified by chromatography on silica eluting with ethyl acetate-methanol (9:1)

Sources & evidence

ORD record
ord-7b09588edd634f87885c6bbdeab30d6f
Source dataset
uspto-grants-2011_09
Patent number
US08017608B2

Reaction notes

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