反应详情

温度

75 °C

Thiosemicarbazide (10 g, 111 mmol) is added in portions to a solution of 3-chloropropionic acid (10 g, 92 mmol) in concentrated sulfuric acid. The mixture is heated with stirring at 75° C. for 1 hour. After cooling to room temperature the reaction mixture id added slowly to water and the resulting solution is brought to pH 7 by addition of aqueous ammonia solution. The titled product precipitates as a yellow solid which is removed by filtration and dried.

1. temperatureThe mixture is heated
2. temperatureAfter cooling to room temperature the reaction mixture id
3. customThe titled product precipitates as a yellow solid which
4. customis removed by filtration
5. customdried