Ammonia → 4-{4-Methyl-2-[5-(2-morpholin-4-yl-ethyl)-[1,3,4]thiadiazol-2-ylamino]-thiazol-5-yl}-benzenesulfonamide

HRID 908186Notes

Reaction equation

HRID 908186 reaction equation
O=[C:2]([CH3:14])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH2:13])(=[O:12])=[O:11])=[CH:6][CH:5]=1.N.[N:16]1([CH2:22][CH2:23][C:24]2[S:28][C:27]([NH:29][C:30]([NH2:32])=[S:31])=[N:26][N:25]=2)[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1>>[CH3:14][C:2]1[N:32]=[C:30]([NH:29][C:27]2[S:28][C:24]([CH2:23][CH2:22][N:16]3[CH2:17][CH2:18][O:19][CH2:20][CH2:21]3)=[N:25][N:26]=2)[S:31][C:3]=1[C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH2:13])(=[O:12])=[O:11])=[CH:6][CH:5]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 215301384-(2-Oxopropyl)benzene-1-sulfonamideHCID 86761402HCID 86761402, compound

Product 1

HCID 867614034-{4-Methyl-2-[5-(2-morpholin-4-yl-ethyl)-[1,3,4]thiadiazol-2-ylamino]-thiazol-5-yl}-benzenesulfonamide

Procedure

The titled compound is prepared from 4-(2-oxo-propyl)-benzenesulfonyl chloride (prepared as described in European patent specification EP 91749 A2) following the procedures described in Example 1, using ammonia and [5-(2-morpholin-4-yl-ethyl)-[1,3,4]thiadiazol-2-yl}-thiourea (54c).

Sources & evidence

ORD record
ord-58a7355d0dba4a35be6ec81a90f074f0
Source dataset
uspto-grants-2011_09
Patent number
US08017608B2

Reaction notes

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