1-Methylpiperazine → 5-(4-Methyl-1-piperazinyl)-1,3,4-thiadiazol-2-amine

Participants

Reaction Steps

A mixture of 1-methylpiperazine (0.742 ml, 6.6 mmol) and bromo-[1,3,4]thiadiazol-2-ylamine (63a) (0.60 g, 3.3 mmol) in n-propanol (15 ml) is heated at reflux for 6 hours. After cooling to room temperature the solvent is removed and the residue is trituated with ethyl acetate and methanol to afford the required compound as a pink solid.

Provenance & Evidence