1-Methylpiperazine → 5-(4-Methyl-1-piperazinyl)-1,3,4-thiadiazol-2-amine

HRID 908194Notes

Reaction equation

HRID 908194 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.Br[NH:9][C:10]1[S:11][CH:12]=[N:13][N:14]=1>C(O)CC>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:12]2[S:11][C:10]([NH2:9])=[N:14][N:13]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 86606224HCID 86606224, compound

Product 1

HCID 15000235-(4-Methyl-1-piperazinyl)-1,3,4-thiadiazol-2-amine

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

A mixture of 1-methylpiperazine (0.742 ml, 6.6 mmol) and bromo-[1,3,4]thiadiazol-2-ylamine (63a) (0.60 g, 3.3 mmol) in n-propanol (15 ml) is heated at reflux for 6 hours. After cooling to room temperature the solvent is removed and the residue is trituated with ethyl acetate and methanol to afford the required compound as a pink solid.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 6 hours
  3. customis removed

Sources & evidence

ORD record
ord-95f8c4dcb3e44a7db815d566ccac8e7a
Source dataset
uspto-grants-2011_09
Patent number
US08017608B2

Reaction notes

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