1-Methylpiperazine → [5-(4-Methanesulfonyl-3-trifluoromethyl-phenyl)-4-methyl-thiazol-2-yl]-(4-methyl-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl-6'-yl)-amine

Participants

Role	Name	HCID	Charge
Reactant	1-Methylpiperazine	HCID 53167	—
Reactant	(6-Chloro-pyrazin-2-yl)-[5-(4-methanesulfonyl-3-trifluoromethyl-phenyl)-4-methyl-thiazol-2-yl]-amine	HCID 86761404	—
Product	[5-(4-Methanesulfonyl-3-trifluoromethyl-phenyl)-4-methyl-thiazol-2-yl]-(4-methyl-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl-6'-yl)-amine	HCID 86761405	—

Reaction Steps

The titled compound is prepared from (6-chloro-pyrazin-2-yl)-[5-(4-methanesulfonyl-3-trifluoromethyl-phenyl)-4-methyl-thiazol-2-yl]-amine (65) and 1-methyl piperazine following the procedure described in Example 13.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08017608B2
Source dataset	uspto-grants-2011_09
ORD ID	ord-8ce0e64558d74f56b0520ea1b94024a1
Source note	uspto-grants-2011_09