1-Methylpiperazine → [5-(4-Methanesulfonyl-3-trifluoromethyl-phenyl)-4-methyl-thiazol-2-yl]-(4-methyl-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl-6'-yl)-amine

HRID 908197Notes

Reaction equation

Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[S:10][C:11]([C:15]3[CH:20]=[CH:19][C:18]([S:21]([CH3:24])(=[O:23])=[O:22])=[C:17]([C:25]([F:28])([F:27])[F:26])[CH:16]=3)=[C:12]([CH3:14])[N:13]=2)[CH:5]=[N:4][CH:3]=1.[CH3:29][N:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1>>[CH3:24][S:21]([C:18]1[CH:19]=[CH:20][C:15]([C:11]2[S:10][C:9]([NH:8][C:6]3[N:7]=[C:2]([N:33]4[CH2:34][CH2:35][N:30]([CH3:29])[CH2:31][CH2:32]4)[CH:3]=[N:4][CH:5]=3)=[N:13][C:12]=2[CH3:14])=[CH:16][C:17]=1[C:25]([F:28])([F:27])[F:26])(=[O:23])=[O:22]

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 86761404(6-Chloro-pyrazin-2-yl)-[5-(4-methanesulfonyl-3-trifluoromethyl-phenyl)-4-methyl-thiazol-2-yl]-amine

Product 1

HCID 86761405[5-(4-Methanesulfonyl-3-trifluoromethyl-phenyl)-4-methyl-thiazol-2-yl]-(4-methyl-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl-6'-yl)-amine

Procedure

The titled compound is prepared from (6-chloro-pyrazin-2-yl)-[5-(4-methanesulfonyl-3-trifluoromethyl-phenyl)-4-methyl-thiazol-2-yl]-amine (65) and 1-methyl piperazine following the procedure described in Example 13.

Sources & evidence

ORD record: ord-8ce0e64558d74f56b0520ea1b94024a1
Source dataset: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08017608B2

Reaction notes

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