反应详情

A solution of NaOH in water (1N, 54 ml, 54 mmol) was added to a suspension of 2-phenyl-imidazo[1,2-a]pyridine-7-carboxylic acid methyl ester (6.8 g, 27 mmol) in a mixture of ethanol (50 ml) and water (25 ml). The mixture was heated to reflux (2 h). The obtained clear solution was cooled, poured onto crushed ice (50 g); HCl (25%, 10 ml) was added. The mixture was then filtered, and the precipitate was washed (ethanol) and dried under vacuum. The obtained solid (6.36 g, 99%) was used in the next step without further purification. MS (m/e)=239.1 [M+H+].

1. temperatureThe mixture was heated
2. temperatureto reflux (2 h)
3. temperatureThe obtained clear solution was cooled
4. additionpoured
5. filtrationThe mixture was then filtered
6. washthe precipitate was washed (ethanol)
7. customdried under vacuum
8. customThe obtained solid (6.36 g, 99%) was used in the next step without further purification