Hydrochloric Acid → HCID 67063182, compound

HRID 908238Notes

Reaction equation

HRID 908238 reaction equation
[OH-].[K+].C([O:5][C:6]([C:8]1[CH:9]=[N:10][N:11]([CH3:31])[C:12]=1[C:13](=[O:30])[NH:14][C:15]1[N:20]=[CH:19][N:18]2[CH:21]=[C:22]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[N:23]=[C:17]2[CH:16]=1)=[O:7])C.Cl>C(O)C>[CH3:31][N:11]1[C:12]([C:13](=[O:30])[NH:14][C:15]2[N:20]=[CH:19][N:18]3[CH:21]=[C:22]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[N:23]=[C:17]3[CH:16]=2)=[C:8]([C:6]([OH:7])=[O:5])[CH:9]=[N:10]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 51034707HCID 51034707, compound

Product 1

HCID 67063182HCID 67063182, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

KOH (15 ml of a solution of 0.26 g in 25 ml ethanol) was added to 1-Methyl-5-(2-phenyl-imidazo[1,2-c]pyrimidin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid ethyl ester (Example 83), and the mixture was heated to reflux overnight. The mixture was cooled to r.t. and acidified with HCl (25%, 0.7 ml). The precipitate was filtered, washed with a small amount of ethanol, and dried under vacuum. The obtained title compound was used without further purification in the next step. MS (m/e)=363.2 [M+H+].

Workup

  1. temperaturethe mixture was heated
  2. temperatureto reflux overnight
  3. filtrationThe precipitate was filtered
  4. washwashed with a small amount of ethanol
  5. customdried under vacuum

Sources & evidence

ORD record
ord-ad5b8b433e614d38a6c26dd000b0296a
Source dataset
uspto-grants-2011_09
Patent number
US08017604B2

Reaction notes

Loading…