Ammonium Hydroxide → HCID 58024787, compound

HRID 908246Notes

Reaction equation

Cl[CH2:2][C:3]1[N:4]=[C:5]2[CH:10]=[CH:9][C:8]([CH3:11])=[N:7][N:6]2[CH:12]=1.[OH-].[NH4+:14]>>[CH3:11][C:8]1[CH:9]=[CH:10][C:5]2[N:6]([CH:12]=[C:3]([CH2:2][NH2:14])[N:4]=2)[N:7]=1

Participants

Reactant 2

HCID 14923Ammonium Hydroxide

HCID 58024817HCID 58024817, compound

Product 1

HCID 58024787HCID 58024787, compound

Conditions

Temperature: 80 °C

Procedure

A mixture of 2-(chloromethyl)-6-methylimidazo[1,2-b]pyridazine (0.6 g, 3.3 mmol) and ammonium hydroxide (25%, 30 ml) was heated to 80° C. in a sealed tube for lhr. The reaction mixture was concentrated under reduced pressure to give title compound as crude product. This material was used in the next step without further purification.

Workup

concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record: ord-9a9af46fdd654894948ce4a423faf42b
Source dataset: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08017605B2

Reaction notes

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