反应详情

To an ethanol 50 mL solution of 2-amino-isonicotinonitrile (5.0 g, 42 mmol) was added 1,3-dichloroacetone (6.93 g, 54.6 mmol). The mixture was heated to reflux for 1.5 hr and cooled to room temperature to give a suspension. The precipitate was collected by suction filtration, washed with dichloromethane and dried to give the title compound (7.2 g). LC/MS: m/z 192(M+H).

1. temperatureThe mixture was heated
2. temperatureto reflux for 1.5 hr
3. customto give a suspension
4. filtrationThe precipitate was collected by suction filtration
5. washwashed with dichloromethane
6. customdried