1,3-Dichloroacetone → 2-(Chloromethyl)imidazo[1,2-a]pyridine-7-carbonitrile hydrochloride

Participants

Reaction Steps

To an ethanol 50 mL solution of 2-amino-isonicotinonitrile (5.0 g, 42 mmol) was added 1,3-dichloroacetone (6.93 g, 54.6 mmol). The mixture was heated to reflux for 1.5 hr and cooled to room temperature to give a suspension. The precipitate was collected by suction filtration, washed with dichloromethane and dried to give the title compound (7.2 g). LC/MS: m/z 192(M+H).

Provenance & Evidence