反应详情

温度

100 °C

To the product obtained in example 22 (40 mg, 0.083 mmol) suspended in H2O (0.5 mL) was added conc. HCl (0.68 mL, 8.31 mmol). The mixture was placed in a microwave reactor and heated to 100° C. for 10 min. Resulting suspension was diluted with 3:1 MeCN:H2O (2 mL) along with DMSO (1 mL) and purified by reverse phase HPLC (C-18 column) to give the title compound (29 mg). LC/MS: m/z 468(M+H). 1H-NMR (600 MHz, d6-DMSO): δ 5.45 (s, 2H), 6.98 (d, 1H), 7.32 (t, 2H), 7.53 (d, 1H), 7.61 (d, 1H), 7.88 (d, 1H), 8.15 (s, 1H), 8.17 (d, 1H), 8.71 (d, 1H).

1. customThe mixture was placed in a microwave reactor
2. customResulting suspension
3. customH2O (2 mL) along with DMSO (1 mL) and purified by reverse phase HPLC (C-18 column)