Water → HCID 59340055, compound

HRID 908571Notes

Reaction equation

HRID 908571 reaction equation
FC(F)(F)C(O)=O.[C:8]([C:10]1[CH:11]=[C:12]([C:16]2[CH:25]=[C:24]3[C:19]([C:20]([OH:39])=[C:21]([C:28]([NH:30][CH2:31][C:32]([O:34]C(C)(C)C)=[O:33])=[O:29])[C:22](=[O:27])[N:23]3[CH3:26])=[CH:18][CH:17]=2)[CH:13]=[CH:14][CH:15]=1)#[N:9].O>ClCCl>[C:8]([C:10]1[CH:11]=[C:12]([C:16]2[CH:25]=[C:24]3[C:19]([C:20]([OH:39])=[C:21]([C:28]([NH:30][CH2:31][C:32]([OH:34])=[O:33])=[O:29])[C:22](=[O:27])[N:23]3[CH3:26])=[CH:18][CH:17]=2)[CH:13]=[CH:14][CH:15]=1)#[N:9]

Participants

5

Reactant 3

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 59340067HCID 59340067, compound

Product 1

HCID 59340055HCID 59340055, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (4.00 ml, 54 mmol) was added to a suspension of tert-butyl 2-(7-(3-cyanophenyl)-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetate (0.162 g, 0.37 mmol) in dichloromethane (2.00 ml). After stirring for one hour at room temperature water was added and the solids formed were collected by filtration. The solids were washed with water, ether, dried in a vacuum oven at 50° C. to afford off-white solids in 74% yield.

Workup

  1. additionwas added
  2. customthe solids formed
  3. filtrationwere collected by filtration
  4. washThe solids were washed with water, ether
  5. customdried in a vacuum oven at 50° C.
  6. customto afford off-white solids in 74% yield

Sources & evidence

ORD record
ord-a1efc1c9b3cb40948f6902baf7e9d300
Source dataset
uspto-grants-2011_09
Patent number
US08017626B2

Reaction notes

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