HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 908584Generated: November 1, 2026
2-Bromo-3-oxobutyric acid tert-butyl ester → 2-[(R)-3-(4-isopropyl-benzylcarbamoyl)-4-(4-trifluoromethyl-benzenesulfonyl)-piperazin-1-yl]-4-methyl-thiazole-5-carboxylic acid tert-butyl ester
https://huagongshe.com/reaction/908584
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Bromo-3-oxobutyric acid tert-butyl ester | HCID 10889938 | — |
| Reactant | (R)-4-thiocarbamoyl-1-(4-trifluoromethyl-benzenesulfonyl)-piperazine-2-carboxylic acid 4-isopropyl-benzylamide | HCID 25055531 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-[(R)-3-(4-isopropyl-benzylcarbamoyl)-4-(4-trifluoromethyl-benzenesulfonyl)-piperazin-1-yl]-4-methyl-thiazole-5-carboxylic acid tert-butyl ester | HCID 25055799 | 85% |
Reaction Steps
A mixture of the compound (250 mg) obtained in Example 4 and 2-bromo-3-oxobutyric acid tert-butyl ester (168 mg) in acetonitrile (1.25 ml) was stirred at 80° C. for 20 min. The reaction mixture was concentrated under reduced pressure, and the residue was purified by thin layer chromatography (ethyl acetate:n-hexane=2:3) to give the title compound (268 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08017612B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-21c10a0ae3194acdb6a940bc806c4331 |
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| Source note | uspto-grants-2011_09 |
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