反应详情

To a solution of the compound (59 mg) obtained in Step 7 in chloroform (0.3 ml) was added, with stirring at room temperature, trifluoroacetic acid (0.3 ml). After stirring at room temperature for 7 hr, the reaction mixture was concentrated under reduced pressure, toluene was added to the residue, and the mixture was concentrated again under reduced pressure. The residue was purified by column chromatography (ethyl acetate:n-hexane=1:2-10% methanol/chloroform) to give the title compound (45 mg).

1. stirringAfter stirring at room temperature for 7 hr
2. concentrationthe reaction mixture was concentrated under reduced pressure, toluene
3. additionwas added to the residue
4. concentrationthe mixture was concentrated again under reduced pressure
5. customThe residue was purified by column chromatography (ethyl acetate:n-hexane=1:2-10% methanol/chloroform)