Hydrochloric Acid → HCID 178517789, compound

HRID 908614Notes

Reaction equation

HRID 908614 reaction equation
N[C:2]1[S:3][C:4]2[C:9]([OH:10])=[N:8][C:7]([C:11]([F:14])([F:13])[F:12])=[N:6][C:5]=2[N:15]=1.N([O-])=O.[Na+].[ClH:20]>>[Cl:20][C:2]1[S:3][C:4]2[C:9]([OH:10])=[N:8][C:7]([C:11]([F:14])([F:13])[F:12])=[N:6][C:5]=2[N:15]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 23668193Sodium NitriteHCID 178508246HCID 178508246, compound

Product 1

HCID 178517789HCID 178517789, compound

Procedure

To a solution of the compound (3.00 g) obtained in Step 6 in 6N hydrochloric acid (45 ml) was added sodium nitrite (8.76 g) in several portions with stirring at room temperature, and the mixture was further stirred at room temperature for 30 min. The precipitated crystals were collected by filtration, washed with water and dried to give the title compound (1.46 g).

Workup

  1. stirringthe mixture was further stirred at room temperature for 30 min
  2. filtrationThe precipitated crystals were collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-51d1426be93840038ab4cccc7e110f01
Source dataset
uspto-grants-2011_09
Patent number
US08017612B2

Reaction notes

Loading…