Hydrochloric Acid → 2-chloro-6H-thiazolo[4,5-d]pyridazin-7-one

HRID 908634Notes

Reaction equation

HRID 908634 reaction equation
N[C:2]1[S:3][C:4]2[C:9](=[O:10])[NH:8][N:7]=[CH:6][C:5]=2[N:11]=1.N([O-])=O.[Na+].[ClH:16]>O>[Cl:16][C:2]1[S:3][C:4]2[C:9](=[O:10])[NH:8][N:7]=[CH:6][C:5]=2[N:11]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 23668193Sodium NitriteHCID 597037542-amino-6H-thiazolo[4,5-d]pyridazin-7-one

Product 1

HCID 597037132-chloro-6H-thiazolo[4,5-d]pyridazin-7-one

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The compound (822 mg) obtained in Step 5 was suspended in 6N aqueous hydrochloric acid solution (6.6 ml), and sodium nitrite (1.69 g) was added in several portions at room temperature. After stirring the obtained suspension at room temperature for 30 min, the reaction mixture was diluted with water, and the solid was collected by filtration, washed with water and a small amount of acetone, and dried to give the title compound (770 mg).

Workup

  1. filtrationthe solid was collected by filtration
  2. washwashed with water
  3. dry with materiala small amount of acetone, and dried

Sources & evidence

ORD record
ord-3a41f7be7bee466fa0c2bb1d8c66a6b5
Source dataset
uspto-grants-2011_09
Patent number
US08017612B2

Reaction notes

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