HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 2-amino-5H-thiazolo[4,5-d]pyridazin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 2-Amino-5-formyl-thiazole-4-carboxylic acid methyl ester | HCID 59703810 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-amino-5H-thiazolo[4,5-d]pyridazin-4-one | HCID 59703821 | — |
Reaction Steps
The compound (788 mg) obtained in Step 3 was suspended in ethanol (7.8 ml), and hydrazine monohydrate (243 μl) and acetic acid (780 μl) were added, with stirring at room temperature. The mixture was stirred overnight at a bath temperature of 100° C. and returned to room temperature. The reaction mixture was concentrated under reduced pressure, and the obtained crude crystals were suspended in methanol, collected by filtration and dried to give the title compound (690 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08017612B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-bcd1f9042c274c25acf7c5d3c3ea2b96 |
| Source note | uspto-grants-2011_09 |