Potassium Hydroxide → HCID 23150782, compound

HRID 908903Notes

Reaction equation

HRID 908903 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[CH2:10][OH:11])=[CH:4][C:3]=1[CH3:12].[OH-].[K+].Cl.Cl[CH2:17][CH2:18][CH2:19][N:20]1[CH2:24][CH2:23][CH2:22][CH2:21]1>>[F:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[CH2:10][O:11][CH2:17][CH2:18][CH2:19][N:20]2[CH2:24][CH2:23][CH2:22][CH2:21]2)=[CH:4][C:3]=1[CH3:12]

Participants

4

Reactant 3

HCID 14797Potassium HydroxideHCID 115719161-(3-chloropropyl)pyrrolidine HydrochlorideHCID 23150777HCID 23150777, compound

Product 1

HCID 23150782HCID 23150782, compoundYield 23.6%

Procedure

Following the procedure described in example 2, but starting from trans-3-(4-fluoro-3-methylphenyl)prop-2-en-1-ol (710 mg), potassium hydroxide (592 mg, 85% wt) and 1-(3-chloropropyl)pyrrolidine, hydrochloride (802 mg) in dimethylsufoxide (6 mL) affords 280 mg of trans-1-{3-[3-(4-fluoro-3-methylphenyl)allyloxy]propyl}-pyrrolidine.

Sources & evidence

ORD record
ord-67b4fa7674334dec8994a411b1c2699b
Source dataset
uspto-grants-2011_09
Patent number
US08017646B2

Reaction notes

Loading…