Potassium Hydroxide → HCID 86621824, compound

HRID 908910Notes

Reaction equation

[OH:1][CH2:2]/[CH:3]=[CH:4]/[C:5]1[CH:13]=[CH:12][C:8]2[O:9]CO[C:7]=2[CH:6]=1.[OH-].[K+].Cl.Cl[CH2:18][CH2:19][CH2:20][N:21]1[CH2:25][CH2:24][CH2:23][CH2:22]1.C([O-])(=O)[C:27]([O-])=[O:28]>>[O:9]1[C:8]2[CH:12]=[CH:13][C:5](/[CH:4]=[CH:3]/[CH2:2][O:1][CH2:18][CH2:19][CH2:20][N:21]3[CH2:25][CH2:24][CH2:23][CH2:22]3)=[CH:6][C:7]=2[CH2:27][O:28]1

Participants

Reactant 4

HCID 14797Potassium Hydroxide

HCID 71081Oxalate

HCID 58697533'-Hydroxyisosafrole

HCID 115719161-(3-chloropropyl)pyrrolidine Hydrochloride

Product 1

HCID 86621824HCID 86621824, compound

Procedure

Following the procedure described in example 2, but starting from trans-5-(3-hydroxyprop-1-en-1-yl)benzodioxolane (400 mg), potassium hydroxide (283 mg, 85% wt) and 1-(3-chloropropyl)pyrrolidine, hydrochloride (376 mg) in dimethylsufoxide (5 mL) affords 90 mg of trans-1-{3-[3-(benzodioxol-5-yl)allyloxy]-propyl}pyrrolidine, oxalate as a white solid melting at 109-111° C.

Sources & evidence

ORD record: ord-f1e4951bd5f64f0b9ede78f476b9043a
Source dataset: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08017646B2

Reaction notes

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