Chlorotrimethylsilane → HCID 11720208, compound

HRID 908921Notes

Reaction equation

HRID 908921 reaction equation
[CH3:1][O:2][C:3](=[O:34])[CH:4]([NH:15][C:16](=[O:33])[CH:17]=[C:18]1[CH2:23][CH2:22][C:21]([N:30]([CH3:32])[CH3:31])([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:20][CH2:19]1)[CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[NH:8][CH:7]=1.[Cl:35][Si](C)(C)C>CC(CC)=O>[ClH:35].[CH3:1][O:2][C:3](=[O:34])[CH:4]([NH:15][C:16](=[O:33])[CH:17]=[C:18]1[CH2:19][CH2:20][C:21]([N:30]([CH3:31])[CH3:32])([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:22][CH2:23]1)[CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[NH:8][CH:7]=1

Participants

4

Reactant 2

HCID 6397ChlorotrimethylsilaneHCID 117202092-[2-(4-Dimethylamino-4-phenylcyclohexylidene)acetylamino]-3-(1H-indol-3-yl)propanoic acid methyl ester

Product 1

HCID 11720208HCID 11720208, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

2-[2-(4-Dimethylamino-4-phenylcyclohexylidene)acetylamino]-3-(1H-indol-3-yl)propanoic acid methyl ester (142 mg, 0.3 mmol) was dissolved in ethyl methyl ketone (9 ml), and chlorotrimethylsilane (0.055 ml, 0.43 mmol) was added. After 2 h it was possible to obtain the product as a colourless compound in a yield of 50 mg (15%) with an m.p. of 164-168° C.

Workup

  1. customto obtain the product as a colourless compound in a yield of 50 mg (15%) with an m.p. of 164-168° C.

Sources & evidence

ORD record
ord-ce60950173184590beb0a9640b90bb4c
Source dataset
uspto-grants-2011_09
Patent number
US08017630B2

Reaction notes

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