Chlorotrimethylsilane → HCID 11568096, compound

HRID 908929Notes

Reaction equation

HRID 908929 reaction equation
[CH3:1][N:2]([CH3:29])[C:3]1([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH2:8][CH2:7][C:6](=[CH:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:11])[CH2:5][CH2:4]1.[Cl:30][Si](C)(C)C>CC(CC)=O>[ClH:30].[CH3:29][N:2]([CH3:1])[C:3]1([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:8][CH2:7][C:6](=[CH:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[O:11])[CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 6397ChlorotrimethylsilaneHCID 11568097HCID 11568097, compound

Product 1

HCID 11568096HCID 11568096, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-(4-phenyl-butyl)acetamide (292 mg, 0.747 mmol) was dissolved in ethyl methyl ketone (5 ml), and chlorotrimethylsilane (0.14 ml, 1.12 mmol) was added. After 1.5 h the hydrochloride was isolated as a colourless solid in a yield of 69% (221 mg).

Sources & evidence

ORD record
ord-effb245f9533461f9b1e04a13fe127ed
Source dataset
uspto-grants-2011_09
Patent number
US08017630B2

Reaction notes

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