Chlorotrimethylsilane → HCID 11596529, compound

HRID 908932Notes

Reaction equation

HRID 908932 reaction equation
[CH3:1][N:2]([CH3:27])[C:3]1([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:8][CH2:7][C:6](=[CH:9][C:10]([NH:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)=[O:11])[CH2:5][CH2:4]1.[Cl:28][Si](C)(C)C>CC(CC)=O>[ClH:28].[CH3:27][N:2]([CH3:1])[C:3]1([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:4][CH2:5][C:6](=[CH:9][C:10]([NH:12][CH2:13][C:14]2[CH:15]=[CH:16][C:17]([F:20])=[CH:18][CH:19]=2)=[O:11])[CH2:7][CH2:8]1

Participants

4

Reactant 2

HCID 6397ChlorotrimethylsilaneHCID 11596530HCID 11596530, compound

Product 1

HCID 11596529HCID 11596529, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-(4-fluorobenzyl)acetamide (252 mg, 0.688 mmol) was dissolved in ethyl methyl ketone (10 ml) with gentle heating and chlorotrimethylsilane (0.126 ml, 1.0 mmol) was added. After 2.5 h the hydrochloride was isolated as a colourless solid with an m.p. of 214-218° C. and a yield of 71% (196 mg).

Workup

  1. temperaturewith gentle heating

Sources & evidence

ORD record
ord-5df26ffe7fab4dbdaf72487f7a7b337f
Source dataset
uspto-grants-2011_09
Patent number
US08017630B2

Reaction notes

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