Chlorotrimethylsilane → HCID 11596529, compound

Participants

Reaction Steps

2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-(4-fluorobenzyl)acetamide (252 mg, 0.688 mmol) was dissolved in ethyl methyl ketone (10 ml) with gentle heating and chlorotrimethylsilane (0.126 ml, 1.0 mmol) was added. After 2.5 h the hydrochloride was isolated as a colourless solid with an m.p. of 214-218° C. and a yield of 71% (196 mg).

Provenance & Evidence